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Overall, although the overall absolute risk increase is small (27 cases per 10,000 persons treated per year), clinical practitioners should nevertheless take into account the potential risk of gallbladder or biliary diseases associated with GLP-1RAs, especially when used at higher doses, for longer durations, and for weight loss, and in case the patient has a history of lithiasis [64]

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The protective effect of SIRT1 is closely related to cytosolic NAD + (Morevati et al., 2021)

SS: Screening and selection of studies, proofreading/correcting manuscript assisting in drawing conclusions from the extracted data

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Additionally, liraglutide decreased the occurrence of nonfatal myocardial infarction and nonfatal stroke