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Oral semaglutide titrated to 14 mg daily reduced 3-point MACE by 14% in SOUL (HR 0.86, 95% CI 0.770.96), with the principal driver a 26% reduction in nonfatal MI

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In the gut specifically, KPV is absorbed through a dedicated intestinal transporter (PepT1), allowing it to calm inflammation directly inside epithelial cells

The compounds primary action involves modulating nitric oxide system activity, which helps stabilize the balance between vasodilation and vasoconstriction, especially in ischemic conditions

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