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This breadth of action distinguishes it from growth factors with a narrow receptor focus and helps explain experimentally observed tissue protection across different organ systems

Even those that are not specifically approved for weight loss have shown significant effects, even when the main concern is targeting diabetes

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doi: 10.2147/DMSO.S209095 [DOI] [PMC free article] [PubMed] [Google Scholar] 177

Nineteen patient samples were incubated for 72 hours with CB-839 (0.5 M) and with venetoclax (10 nM), AZD-5991 (250 nM), or ibrutinib (1 M) with or without CB-839

Administration of 25-hydroxyvitamin D3 or calcitriol (fully activated vitamin D3, a very potent substance available only by prescription) lowered measures of inflammation and improved bone health in 37 patients with Crohns disease in remission (Miheller 2009)