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Patients should also contact their provider before starting semaglutide if they have a history of pancreatitis, severe gastrointestinal disease, diabetic retinopathy, medullary thyroid carcinoma, or MEN2

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The GLP-1R is expressed on a small subset of murine intrahepatic endothelial and T cells, and genetic elimination of Glp1r in these cells attenuated the anti-inflammatory actions of semaglutide in the livers of HFD-fed mice [120]