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For example, unrestricted ketogenic diets have been shown to increase mortality in mice, and supplementing the OHB precursor 1,3-butanediol has been shown to increase middle-aged mortality in normal mice but extend lifespan in aged mice (Tomita et al

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Nan YM, Wu WJ, Fu N et al (2009) Antioxidants vitamin E and 1-aminobenzotriazole prevent experimental non-alcoholic steatohepatitis in mice