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Furthermore, TAK1 activates mitogen-activated protein kinases and NF-B to trigger the production of proinflammatory cytokines 49

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Important: Current published data is strictly limited to laboratory, cell culture, and preclinical animal models

For instance, in pulmonary arteries, high-altitude residence and animals exposed to artificial ambient hypoxic conditions thicken the arterial wall and increase the production of extracellular matrix proteins (Rabinovitch et al., 1979