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Given that there is no placebo-controlled human data, no established dose, and a mechanism whose foundational papers were retracted, an absence of noticeable effect is fully consistent with the current evidence it does not necessarily indicate a defective product, the wrong route, or an insufficient duration

Thomsen MS, Johnsen KB, Kucharz K, Lauritzen M, Moos T

Blood 139:24132414 Nemkov T, Reisz JA, Xia Y, Zimring JC, DAlessandro A (2018) Red blood cells as an organ

Author disclaimer The views expressed are those of the authors and do not necessarily reflect those of the Amsterdam UMC location AMC

MOTS-c is often provided as a lyophilized powder that must be reconstituted with bacteriostatic water using sterile technique before use