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However, in healthy rats, it may decrease (PS) or increase (LES) the pressure in sphincters[2]

Poly(ADP-ribose) polymerase is a catalytic dimer and the automodification reaction is intermolecular

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Their therapeutic action is predicated on a confluence of mechanisms, including increased nitric oxide (NO) bioavailability, reduced oxidative stress, and the intricate modulation of vasoactive signaling cascades

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