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The catalytic tetrad formed by Sec, glutamine, tryptophan and asparagine is essential for GPx activity, since these residues are crucial for enzyme-substrate interaction and stabilization of the GSH-GPx interaction [47, 65, 66]

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Zetterstrom, O., Johanson, S.G.O., IgE concentrations measured by PRIST in serum and healthy adults and in patients with respiratory allergy, Allergy 36:537 (1981)