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Deep vein thrombosis symptoms include: Swelling in one leg (rarely both) Pain or tenderness, often starting in the calf Warmth in the affected area Red or discolored skin Prominent veins may sometimes be visible (though this alone is nonspecific) Pulmonary embolism symptoms include: Sudden shortness of breath Chest pain that worsens with deep breathing or coughing Rapid or irregular heartbeat Coughing up blood Lightheadedness or fainting These symptoms require immediate medical evaluation regardless of medication use

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Typical TGR inhibitor studies utilize a 15-minute preincubation step of enzyme, NADPH, and inhibitor