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2022 Dec;186:106550

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As a side note, the observed modest response for the DMSO control was also incorporated into the model to take into account that a minor part of the pathway activation observed under the experimental conditions used is due to DMSO rather than DEM (see Supplement)

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Pharmacists may wish to lengthen the duration between starting dose and dose increase, and should routinely check the summary of product characteristics (SPC) for individual drugs for more information