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The high heterogeneity in terms of type of coffee, doses and duration of the studies, the lack of information on coffee and/or brew bioactive composition, as well as the choice of biomarkers and the methods used for their evaluation, may partially explain the variability observed among findings

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By slowing gastric emptying and signaling satiety to the brain, they can cause side effects like nausea, vomiting, or diarrhea, especially when first introduced

Neurochem Int 29:145152 Sekhon B, Sekhon C, Khan M, Patel SJ, Singh I, Singh AK (2003) N -acetyl cysteine protects against injury in a rat model of focal cerebral ischemia

Pregnancy, Breastfeeding, and Fertility Pregnancy: If you are pregnant, Amitriptyline is generally considered a safe medication to use