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Whenever significant weight loss occurs, some muscle loss can happen alongside fat loss

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Exenatide treatment exerts anxiolytic- and antidepressant-like effects and reverses neuropathy in a mouse model of type-2 diabetes

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Trulicity is clinically similar to Ozempic (both are GLP-1 receptor agonists), though head-to-head trials show semaglutide produces slightly greater A1C reduction and weight loss (Nauck et al., Lancet Diabetes & Endocrinology 2021)