First-line therapy for HH is topical formulations
The flexibility of this array kit allows customization in the number and the preferred variants onto the membrane template, suited to the local requirements ( Glucose-6-Phosphate Dehydrogenase Activity in Relation to Gene Mutation Position of Mutation Biochemically, there is a huge correlation between the position of mutation and the severity of deficiency
Specifically, neuropeptide Y/agouti-related protein (NPY/AgRP) neurons control appetite by the orexigenic effect47), and pro-opiomelanocortin/cocaine- and amphetamine-regulated transcript (POMC/CART) neurons are sensitive to peripheral hormones such as insulin and leptin by anorexigenic effects48)
is supported by the Singapore International Graduate Award (SINGA) by A*STAR
Additionally, tirzepatide acts on areas of the brain involved in appetite regulation, leading to reduced hunger and increased feelings of fullness
Data sources Orforglipron ATTAIN-1 trial: Eli Lilly press release (August 2025) Tirzepatide SURMOUNT-1 trial: Eli Lilly published data Indirect comparison metaanalysis: Circulation (2024) GI adverse events metaanalyses: Endocrinology, Diabetes & Metabolism (2024) and Diabetes, Obesity and Metabolism (2023)
