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HuBOuyangYZhaoTWangZYanQQianQet alAntioxidant hydrogels: Antioxidant mechanisms, design strategies, and applications in the treatment of oxidative stress-related diseases

Together, these findings suggest that KYN-driven oxidative stress is not merely an epiphenomenon of depression but a mechanistic contributor to mitochondrial dysfunction, neuroprogression, and systemic comorbidity, highlighting redox modulation as a critical interface between inflammation, KP activity, and depressive pathology

The peptides act through different pathways, but robust human clinical trials establishing the safety and effectiveness of combining them for wellness or recovery are lacking

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J Cell Mol Medi