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N-acetylcysteine dose-dependently improves the analgesic effect of acetaminophen on the rat hot plate test

As the liver is also the major site for one-carbon metabolism, which is dysregulated in MASLD 16 , glycine treatment may benefit liver health through this mechanism

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Mechanistically, shikonin could regulate glycolysis and ATP production by inhibiting GLUT1, PKM2 and HK2 alone, which was verified by knocking down PKM2 expression in RAFLSs

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GLP-1R binds to ligands to internalize GLP-1R, and can independently reduce TG accumulation in hepatocytes by activating key signaling molecules downstream of insulin receptor substrate 2 (IRS2)