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In addition, Nrf2 can inhibit the transcription of NF-B[104] and the encoding of proinflammatory genes, including interleukin 6 (IL-6) and IL-1[105]

Comparative effectiveness of SGLT2 inhibitors, GLP-1 receptor agonists, DPP-4 inhibitors, and sulfonylureas on risk of kidney outcomes: emulation of a target trial using health care databases

55,268 High glucose levels impair mitochondrial oxidative phosphorylation, decreasing ATP production and increasing ROS generation

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