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Achieving greater systemic exposure with a lower administered dose can reduce pill burden and support sustained supplementation, thereby enhancing the feasibility of long-term use. Source: Antioxidants

These differences in adherence rates across various medications and use cases are illustrated in Figure 3

It was experimentally determined that the antihypertensive effect of vitamin C is expected to occur at a concentration of 10 mM, 103 which is an unattainable plasma level in humans through oral administration

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In response to the significant evidence gap in the current field, there is an urgent need to conduct more large-scale, multi-center, long-term follow-up randomized controlled trials (RCT) targeting the elderly and sarcopenia populations