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Patients should reach out if they experience persistent nausea, vomiting, or diarrhea that prevents adequate nutrition or hydration (which may lead to dehydration and kidney problems)
Intern Med
Cooled the mixture to 25-30C and stirred for 2 hr at same temperature
Be sure to use a new needle for each injection and follow proper technique to avoid injury or infection
Table 1 Abbreviations and respective meanings thereof Fmoc 9-fluorenylmethoxycarbonyl 2-CTC-Resin 2-chlorotrityl chloride resin tBu tert-butyl OtBu tert-butoxy Alloc allyloxycarbonyl DCM dichloromethane DBLK 20% hexahydropyridine/DMF solution DIPEA N,N- diisopropylethylamine HOBt 1-hydroxybenzotriazole HOAt 1-hydroxy-7-azobenzotriazole PyBOP benzotriazol-1-yl-oxytripyrrolidinyl hexafluorophosphate DMSO dimethyl sulfoxide HATU O -(7-azobenzotriazole)-N,N,N',N'-tetramethyluronium hexafluorophosphate HPLC High Efficiency Liquid Chromatography DMF N,N - the raw materials and reagents used in the preparation method of Semaglutide provided by the present invention are all commercially available
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