[3] A 2026 systematic review in The BMJ puts rebound into a broader frame: after stopping weight management medications, average regain was estimated at roughly 0.4 kg per month , with faster regain after newer incretin drugs, and cardiometabolic markers projected to return toward baseline within roughly 1.4 years after stopping
However, the FDA approves these medications as adjuncts to reduced-calorie diet and increased physical activity for optimal results
The amount of weight loss you can expect from appetite suppression with semaglutide GLP-1 varies depending on individual factors such as your starting weight, lifestyle, and adherence to the treatment plan
Kidney problems: If you have existing kidney problems, diarrhea, nausea, and vomiting may cause dehydration, which can worsen your condition and possibly result in kidney failure
Snacks that serve a purpose On semaglutide, snacking should be strategic rather than habitual
This is a large, carefully designed observational study not a randomised trial so it points to a promising signal rather than a proven benefit