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Resveratrol ameliorates sepsis-induced acute kidney injury in a pediatric rat model via Nrf2 signaling pathway

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doi: 10.1371/journal.pone.0262598

found that caffeine inhibits AKT/mTORC1 signaling by blocking FASN-dependent MyD88 palmitoylation, which ameliorates hepatic steatosis and inflammatory injury in MASH mice in vivo (206)

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This is in contrast with the beneficial effects reported previously for the triagonist, in terms of reversion of adiposity excess and improved metabolic profile in diet-induced obese female mice 42 , suggesting that hyperandrogenism is bound to particular metabolic features that require specific multi-agonist treatments for maximum efficacy