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Multiple molecular mechanisms have been implicated in PD pathogenesis, including mitochondrial dysfunction, oxidative stress, impaired protein degradation pathways (ubiquitin-proteasome and autophagy-lysosomal systems), excitotoxicity, calcium dysregulation, neuroinflammation, and abnormal alpha-synuclein aggregation

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Disruption of hepatic adipogenesis is associated with impaired liver regeneration in mice

The top 10 most significantly altered canonical pathways are demonstrated in Table 2 (with all significantly altered pathways displayed in Supplementary Table S1 )

Stool that is consistently pale also suggests a lack of bile secretion, and the same recommendations for rapid weight loss would apply