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M.LeeH.et al (2009)

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In humans suffering from obesity, daily systemic injections of liraglutide did not ameliorate OA-related pain, probably because of poor access and hence poor local concentrations of liraglutide in the knee joint 44

Mouse models of MTHFR deficiency The Mthfr of mice were knockout to investigate MTHFR deficient by animal models 38

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Activation of GIP receptors may further support fat metabolism and insulin sensitivity, whilst glucagon receptor agonism is believed to increase energy expenditure and promote the breakdown of stored fat (lipolysis)