These exons encode, apart from the 5 untranslated region, a portion of the signal peptide(s) for secretion, and their use seems dependent on two different promoters that are regulated in a tissue-specific manner 17
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It is formed from three amino acids glutathione, cysteine, and glycine, present in two forms which are oxidized (GSSG) and reduced (GHS)
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Beyond FSP1 there are therapeutic opportunities across the CoQ 10 oxidoreductase network While FSP1 currently has the strongest targetability signal, other CoQ 10 oxidoreductases may be therapeutically leveraged in defined genetic, metabolic or tissue contexts: (1) DHODH axis (mitochondrial defense in select contexts): DHODH connects pyrimidine synthesis to mitochondrial CoQ reduction, and in some settings, DHODH inhibition has been proposed to heighten ferroptosis sensitivity, especially in GPX4-low states