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In December 2024, the TRIUMPH-4 Phase 3 trial results were announced, showing that participants taking retatrutide 12 mg achieved an average weight loss of 71.8 pounds or 28.7% of body weight over 68 weeks

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There is also Ozempic, which is only FDA-approved to treat type 2 diabetes, but there has been news about prescribing it off-label for weight loss benefits

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Other analogues with marked efficacy in preclinical studies, including non-peptide AMYR agonists are under development. Promising Candidates in Development At this point, it is hard to say which, if any, of these candidates will turn out to deliver important clinical advantages

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