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Exposure to ultraviolet radiation is the most important factor that causes undesirable hyperpigmentation

Interestingly, the infiltration of Th1 and Th17 cells into the CNS, as well as the secretion of cytokines by CD4+ T cells, could also be initiated by ferroptotic neurons, which were induced by over-expression of ACSL4 (a regulator of PUFA-PLs synthesis) (58)

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More noticeable changes in skin tone typically take 12-16 weeks, though individual results vary significantly based on skin type, concern severity, and product formulation