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Key safety concerns include potential insulin sensitivity effects linked to certain CLA isomers and the possibility that L-carnitine increases TMAO via gut bacteria in some people which has been associated with cardiovascular risk in observational studies

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Given the heterogenic nature of NAFLD, targeting metabolic, anti-inflammatory, or anti-fibrotic disease pathways simultaneously may exert an additive or synergistic effect and combination therapy may prove to be a an important tool in the future development of pharmacological treatment options

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The STEP 2 trial [2] , which included participants with type 2 diabetes, showed slightly more modest but still substantial results, with 9.6% average weight loss compared to 3.4% with placebo

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