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Low-dose methotrexate inhibits methionine S-adenosyltransferase in vitro and in vivo

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Lactate-induced excess secretion of IFN- activates c-Jun N-terminal kinase (JNK)/c-JUN, p38-MAPK signaling, and finally inhibits the normal functioning of cytotoxic T lymphocytes (CTL) (233)

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