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Since its isolation and characterisation in the early 1990s, it has become one of the most extensively studied peptides in regenerative biology research, with a broad research profile spanning gastrointestinal, musculoskeletal, vascular, and neurological tissue models

The NLRP3 inflammasome stimulation by sUA is accompanied by cellular redox state changes, increasing in mitochondria area and mitochondrial ROS production

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CONCLUSIONS Together, this evidence suggests that oxidative stress and in particular disturbed glutathione metabolism are related to the pathogenesis of hypertension

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