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Moreover, it caused nuclear p53 exclusion and induced apoptosis selectively in senescent Leydig cells by disrupting the FOXO4-p53 interaction, which may be a critical mechanism underlying its therapeutic effect

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However, since this publication, national organizations have published guidelines that are divergent in their approach to screening and diagnosis of GDM (276280), thus perpetuating the international lack of consensus on the criteria for diagnosis of GDM

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