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in those specifically with cardiac hemochromatosis, large doses of vitamin C supplementation can lead to rapid mobilization of iron from the heart, leading to potentially fatal cardiac arrythmias

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In order to maintain trial assay sensitivity, allowed use of background concomitant therapies and addon therapies that have the potential to impact the assessment of efficacy for weight management, glycemic control, management of OSA and management of OA pain are specified in the respective studies (Table S2)

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Advances in peptide chemistry and analytical technologies enabled detailed investigation of peptide-mediated communication pathways and molecular regulatory mechanisms