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Rutin has been evaluated in a previous study of intestinal toxicity induced by MTX, and this study showed its ability to attenuate intestinal oxidative stress changes by lowering intestinal MDA and boosting GSH content and SOD activity

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For this purpose, levels of COX2, which initiates the formation of inflammatory and painful prostaglandins, MDA, a reliable marker of lipid peroxidation and oxidative stress 72 , and TNF-/ IL-6, potent inflammatory cytokines in rats were estimated

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