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Semaglutide is a synthetic lipopeptide (peptide conjugated with a fatty acid chain similar to liraglutide) with a linear sequence of 31 amino acids
Phentermine-topiramate extended-release (Qsymia) combines a sympathomimetic amine with an anticonvulsant to suppress appetite and enhance satiety, but is contraindicated in pregnancy and uncontrolled hypertension
For those also managing weight alongside blood sugar, it may be worth comparing options like the Ozempic pen against other GLP-1 options
Surprisingly, the incidence of T2DM in PWS individuals is lower than expected (165, 182), indicating they have a healthier metabolic profile compared to weight-matched healthy individuals
Thus, without going into too many methodological details, there are questions about whether or not the approach used in this study fully explored (or rules out) the role of GLP-1 in the hypoglycaemic response