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Given proposed opioid and sedative mechanisms, combining DSIP with CNS depressants, opioid medications, or benzodiazepines should be avoided without direct medical supervision

Amino Acids 48 , 859872 (2016)

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doi: 10.2337/diabetes.54.2.482 57 ElsnerMGehrmannWLenzenS

Total lysates were passed ten times through a 25-gauge needle with a syringe, kept at 4 C for 10 min and then cleared by centrifugation in a microcentrifuge (14,000 rpm at 4 C for 10 min)