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Shim JA, Son YA, Park JM, Kim MK

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The IRS1/Akt pathway is critical for regulation of metabolism by insulin and InsR

Glutathione when used as a supplement for skin whitening has been shown to be safe and effective in numerous clinical studies, and according to a double-blind placebo-controlled clinical trial by National Institute of Health [1], Glutathione treatment has been proven to significantly lower the skin melanin index of study participants after a few weeks of use

In parallel, it suppresses the expression of pro-apoptotic markers including Bax and cleaved caspase-3, thereby preserving granulosa cell integrity and delaying ovarian aging [162]