Semaglutide occupies those receptors for roughly seven days per dose because of its half-life of approximately 165 hours [2]
When the last injection clears, circulating GLP-1 receptor agonist activity drops to zero, and the central nervous system reverts to its pre-drug set-point within two to four weeks
Each individuals GLP-1 journey is unique, shaped by personal health history, lifestyle, and outcomes
A typical tapering protocol reduces the dose by 25 to 50% every four weeks, mirroring the same step-down intervals used during dose escalation
Once you stop the medication, this adaptive thermogenesis can make regaining weight easier unless you've built sustainable lifestyle habits
Or squeeze in small bouts of movement even when you cant make time for a long workout