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HFE can also reverse the TMAO-induced decrease of antioxidant capacity by upregulating the expression of antioxidant enzymes including superoxide dismutase 1 (SOD1), SOD2, glutathione peroxidase 3 (GSH-Px3), and catalase (CAT) in the liver
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IL-6, a key proinflammatory cytokine, is upregulated in multiple OA-related joint compartments, including synovial tissue, cartilage, and synovial fluid, where it promotes matrix degradation and inflammation (39)
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