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Instead the range of laboratory reference values are shifted downward to reflect those in human subjects as they advance in age

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502 In addition, studies have found that probiotics can adjust the changes of intestinal flora to reduce inflammation and IR, so probiotics may be an important supplement for the treatment of IR

[24] [25] For patients with confirmed pathological hypercortisolism (Cushing's syndrome), definitive treatment depends on etiology and may include transsphenoidal surgery for pituitary adenomas, adrenalectomy for adrenal tumors, or medical therapy

Thus, it may impair the basal membrane of the vascular wall and may contribute to LDL sequestration (McCully, 1983

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