Here, we report that the combination therapy of As 2 O 3 with L-buthionine-sulfoximine (BSO), which inhibits a critical step in glutathione synthesis, effectively enhanced in vitro growth inhibition effect of As 2 O 3 on all 11 investigated cell lines arising from prostate, breast, lung, colon, cervix, bladder, and kidney cancers, compared with As 2 O 3 treatment alone
This process involves slow introduction of the drug at low doses until an effective dose is reached and tolerated by the individual
1 The primary reason is that peptide-based drugs can be highly effective, 2 leading to fewer off-target interactions and excellent biocompatibility
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H., Rydevik, B
Enrichment of humoral immune response (GO:0006959) and immunoglobulin-mediated immune response (GO:0016064) likely reflects differences in antigen receptor profiles arising from immune responses generated against SARS-CoV-2 infection