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Neurological: melanocortin receptor activity and central signaling

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In those with a genetic predisposition to T2D, it is widely believed that elevated concentrations of circulatory long-chain fatty acids (LC-FFA) significantly contribute towards the demise of insulin-producing pancreatic -cells the fundamental feature of the development of T2D

251 Impaired neurotrophic support In DPN, levels of neurotrophic factors are significantly reduced due to hyperglycemia-induced metabolic disturbances