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In contrast, METTL3 exerts dual and context-dependent effects: in thoracic aortic dissection, METTL3 elevation correlates with suppressed SLC7A11 and FSP1 expression, enhancing ferroptotic sensitivity [66]

References Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM, et al

Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK-SIRT1-PGC1 axis in db/db mice

These combined mechanisms lead to improved glycemic control and significant weight loss in clinical trials

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