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One of their effects is suppressing appetite and reducing hunger

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Serotonergic signalling is terminated primarily by the uptake of 5-HT from the synaptic cleft back into the presynaptic neuron

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In some embodiments, the formulations or compositions described herein have a pH between about 3 and about 9, or between about 4 and 8, or between about 5 and 8, or between about 6 and about 7, or between about 6.5 and about 7, or between about 5.5 and about 7.5, or between about 7.1 and about 7.7, and have a concentration of active pharmaceutical ingredient between about 0.1 mM and about 100 mM