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Advanced glycation end-products (AGEs) create abnormal cross-links that stiffen collagen fibers, reducing their ability to support smooth skin and increasing brittleness that leads to deeper wrinkle formation

Going back to the IEL cells for a moment, in Crohns disease and ulcerative colitis (UC) these cells can start to attack the gut lining itself, this further creates a cytotoxic environment, which can further exacerbate IELs to produce pro-inflammatory proteins, this can lead to a compromised intestinal lining, along with alterations in the gut microbiome