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The DNMT1 protein faithfully maintains the pattern of methylated CGs that would otherwise become lost through cell divisions, whereas the de novo methyltransferases, DNMT3a/b, can also catalyze non-CG methylation (Suetake et al., 2003

doi: 10.1172/JCI60047

Advantages of Injectable GLP-1 Drugs# Higher Peak Efficacy# Injectable formulations currently deliver higher peak weight loss: Best injectable: Tirzepatide at 20.9% (72 wk), retatrutide at 28.7% (68 wk) Best oral: Oral semaglutide 50 mg at 15.1% (68 wk), aleniglipron at 15.3% (36 wk, placebo-adjusted) For patients seeking maximum weight loss, injectables remain the more potent option as of early 2026

doi:10.1159/000118012 van Kammen DP, Widerlv E, Neylan TC, Ekman R, Kelley ME, Mouton A, Peters JL

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Psychosomatic Medicine , 80 (2), 154-159