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When sulfonylurea is contraindicated or not tolerated, dual treatment with metformin and other antidiabetic medications such as -glucosidase inhibitors, repaglinide, or dipeptidyl peptidase 4 (DPP4) inhibitors may be initiated [4]

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The DDD-Ube2e2-COP1-c-Jun complex co-expressed with STK40 exhibited an overall structure similar to that without STK40, with an additional weak density localized to the COP1 dimerization region (Supplementary Figs