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Consideration for future in vitro BBB models - technical development to investigate the drug delivery to the CNS

Some protocols combine approaches, using local injection near primary wounds with periodic systemic dosing for comprehensive support

Aggarwal A, Wadhwa R, Kapoor D, Khanna R

For instance, while some trials use standardized doses over controlled periods, others vary considerably in their protocols, making it difficult to compare their outcomes 51 directly

Similarly, QSYQ has been shown to regulate energy metabolism in a rat model of cardiac I/R injury (Lin et al., 2013

doi: 10.1055/s-0039-1692406 114 dos SantosVMCorraFGBarbosa JuniorERLealM