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A considerable fraction of DSBs can also be formed in cells through indirect mechanisms

elegans 18,33 , we observe that 24 h of fasting in early adulthood was sufficient to extend median lifespan by 40.8% (Fig

This reduction step occurs via oxidation of GSH to GSSG, and the GSSG is subsequently reduced back to GSH in the body via the enzyme glutathione reductase and NADPH 591

Following whole-body deletion of Gclc , adult mice rapidly lose weight and die, but not before showing a reduction in circulating triglyceride levels

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doi: 10.1155/2023/1068000 103 RohrhoferJGraningerMLettenmaierLSchweighardtJGentileSAKoidlLet al