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Additionally, we discuss the underlying mechanisms and clinical challenges, providing valuable insights into identifying novel targets and exploring combination therapies to refine the study model and enhance clinical value

3.4 Appetite regulation and weight management Similar to animal studies with deletion of the GIPR gene that exhibit protection toward obesity ( GIPR gene to be associated with BMI (103)

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2 According to a press release, the partnership will bring together a multidisciplinary team of scientists, AI researchers, and engineers to work together on solving drug discovery problems

Of note, these data demonstrate that the body weight and food intake reducing effects of GIPR antagonism not only depend on functional GIPR signalling, but also on GLP-1R signalling