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1,23 Weight loss is maintained with long-term treatment, as shown by a 2-year follow-up study of dapagliflozin treatment that demonstrated sustained fat-mass reduction over the study period
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Abbreviations T2DM: Type 2 diabetes mellitus GLP-1RAs: Glucagon-like peptide-1 receptor agonists GIP: Glucose-dependent insulinotropic peptide hsCRP: High-sensitivity C-reactive protein IL: Interleukin MD: Mean difference CI: Confidence intervals SE: Standard error MASLD: Metabolic dysfunction-associated steatotic liver disease MCP-1: Monocyte chemoattractant protein-1 References NCD Risk Factor Collaboration (NCD-RisC)
& Norian, L
iHuman Institute, ShanghaiTech University, Shanghai, China
The prevalence of mutations associated with this condition reach 68% to 81% in certain arctic coastal populations, suggesting that the condition had some adaptive value in those habitats at some time
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