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The pairing logic above is mechanistic and based on CagriSema results

For example, biased GLP-1R signalling is observed following stimulation with exendin-phe1, which carries a phenylalanine substitution at position 1 of exendin-4, causing a similar reduction in receptor internalisation and increased plasma membrane recycling to GLP-1R V229A (60)

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Stop the medication if you are experiencing these symptoms and consult with your healthcare provider before taking the next dose

10.1046/j.1460-9568.2000.00126.x 141